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In this work, the Kármán–Pohlhausen (KP) momentum-integral approach based on optimized fourth-order (MX4) polynomial approximations of the velocity and temperature profiles is applied to a classical benchmark problem, namely, that of a cylinder in crossflow with a variable pressure gradient. This enables us to extract closed-form expressions for both hydrodynamic and thermal boundary-layer parameters and then compare the newly found solutions to their counterparts obtained using Pohlhausen's cubic (KP3) and quartic (KP4) polynomials. As usual, the farfield around the cylinder is modeled using potential flow theory and the momentum-integral analysis is paired with Walz's empirical expression for the momentum thickness, which is based on a wide collection of experiments. This procedure permits retrieving explicit relations for the pressure-sensitive KP3, KP4, and MX4 velocity profiles across the boundary layer; one also obtains accurate approximations for the pressure distribution around the cylinder as well as an improved prediction of the separation point, namely, to within 0.87% of the actual location. In this process, refined estimates are produced for several characteristic parameters whose distributions are found to be in favorable agreement with experimental measurements and numerical simulations. These include the disturbance, momentum, and displacement thicknesses as well as the skin friction, pressure, and total drag coefficients. Finally, the thermal analysis is undertaken using both isothermal and isoflux boundary conditions. For each of these cases, closed-form analytical solutions are obtained for the local Nusselt number distribution around the cylinder, and these distributions are found to exhibit noticeably reduced errors relative to their classical values.